Publication Date
11-1-2022
Journal
Langenbeck's Archives of Surgery
Abstract
PURPOSE: Adequate pulmonary function is important for patients undergoing surgical resection of esophageal cancer, especially those that received neoadjuvant therapy. However, it is unknown if pre-operative radiation affects pulmonary function differently compared to chemotherapy. The purpose of this study was to compare changes in pulmonary function between patients undergoing minimally invasive esophagectomy (MIE) who received neoadjuvant chemotherapy or chemoradiotherapy.
METHODS: Between March 2017 and March 2018, esophageal cancer patients requiring neoadjuvant therapy were prospectively enrolled and randomly assigned to receive chemotherapy (CT) or chemoradiotherapy (CRT) before MIE. All patients received pulmonary function testing before and after the neoadjuvant therapy. Changes in pulmonary function, operative data, and pulmonary complications were compared between the 2 groups.
RESULTS: A total of 71 patients were randomized and underwent MIE after receiving CT (n = 34) or CRT (n = 37). Baseline clinical characteristics were comparable between the 2 groups. The CRT group experienced a greater decrease of forced expiratory volume at 1 s (FEV
CONCLUSIONS: Preoperative CRT affects pulmonary function more than CT alone, but does not increase the risk of pulmonary complications in patients undergoing MIE.
Keywords
Humans, Esophagectomy, Neoadjuvant Therapy, Esophageal Neoplasms, Chemoradiotherapy, Lung, Esophageal cancer, Neo-adjuvant therapy, Pulmonary function
Included in
Medical Sciences Commons, Mental and Social Health Commons, Oncology Commons, Radiation Medicine Commons, Surgery Commons
Comments
Supplementary Materials
PMID: 36006505