Faculty, Staff and Student Publications
Molecular Genetic Approaches To Defining Lipid Function
Language
English
Publication Date
4-1-2009
Journal
Journal of Lipid Research
DOI
10.1194/jlr.R800041-JLR200
PMID
18980944
PMCID
PMC2674694
PubMedCentral® Posted Date
April 2009
PubMedCentral® Full Text Version
Post-print
Abstract
Lipids fulfill multiple and diverse functions in cells. Establishing the molecular basis for these functions has been challenging due to the lack of catalytic activity of lipids and the pleiotropic effects of mutations that affect lipid composition. By combining molecular genetic manipulation of membrane lipid composition with biochemical characterization of the resulting phenotypes, the molecular details of novel lipid functions have been established. This review summarizes the results of such a combined approach to defining lipid function in bacteria.
Keywords
Lipid Metabolism, Lipids, Phospholipids, Signal Transduction
Published Open-Access
yes
Recommended Citation
William Dowhan, "Molecular Genetic Approaches To Defining Lipid Function" (2009). Faculty, Staff and Student Publications. 268.
https://digitalcommons.library.tmc.edu/uthmed_docs/268