Emerging Variants Develop Total Escape From Potent Monoclonal Antibodies Induced by BA.4/5 Infection
Publication Date
4-16-2024
Journal
Nature Communications
Abstract
The rapid evolution of SARS-CoV-2 is driven in part by a need to evade the antibody response in the face of high levels of immunity. Here, we isolate spike (S) binding monoclonal antibodies (mAbs) from vaccinees who suffered vaccine break-through infections with Omicron sub lineages BA.4 or BA.5. Twenty eight potent antibodies are isolated and characterised functionally, and in some cases structurally. Since the emergence of BA.4/5, SARS-CoV-2 has continued to accrue mutations in the S protein, to understand this we characterize neutralization of a large panel of variants and demonstrate a steady attrition of neutralization by the panel of BA.4/5 mAbs culminating in total loss of function with recent XBB.1.5.70 variants containing the so-called 'FLip' mutations at positions 455 and 456. Interestingly, activity of some mAbs is regained on the recently reported variant BA.2.86.
Keywords
Humans, Antibodies, Monoclonal, Mutation, Postoperative Complications, SARS-CoV-2, Antibodies, Neutralizing, Antibodies, Viral
Included in
Biological Phenomena, Cell Phenomena, and Immunity Commons, COVID-19 Commons, Epidemiology Commons, Internal Medicine Commons, Mental and Social Health Commons
Comments
Supplementary Materials
PMID: 38627386