Faculty, Staff and Student Publications
Publication Date
9-6-2022
Journal
Methodist Debakey Cardiovascular Journal
Abstract
Heart failure can lead to renal impairment, an interaction now termed "cardiorenal syndrome." The prevalent physiological explanation for the renal impairment that accompanies heart failure centers around the forward failure hypothesis, which emphasizes the role of left ventricular dysfunction in causing edema, and the backward failure hypothesis, which singles out venous congestion as the dominant mechanism of edema and reduced glomerular filtration rate. In this review, we provide an appraisal on venous congestion, an extremely important contributor that has received little attention. We also summarize the pharmacology of loop diuretics, explain current understanding of diuretic resistance, and address controversies regarding decongestive treatments.
Keywords
heart failure, cardiorenal syndrome, venous congestion, glomerular filtration rate
Included in
Cardiology Commons, Cardiovascular Diseases Commons, Internal Medicine Commons, Medical Sciences Commons, Mental and Social Health Commons, Nephrology Commons, Pathological Conditions, Signs and Symptoms Commons, Surgery Commons
Comments
PMID: 36132580