High Expression of TROP2 Is Associated With Aggressive Localized Prostate Cancer and Is a Candidate Urinary Biomarker

Authors

Shiqin Liu
Sarah J Hawley
Christian A Kunder
En-Chi Hsu
Michelle Shen
Lennart Westphalen
Heidi Auman
Lisa F Newcomb
Daniel W Lin
Peter S Nelson
Ziding Feng
Maria S Tretiakova
Lawrence D true
Funda Vakar-Lopez
Peter R Carroll
Jeffry Simko
Martin E Gleave
Dean A Troyer
Jesse K McKenney
James D Brooks
Michael A Liss
Tanya Stoyanova

Publication Date

1-4-2024

Journal

Scientific Reports

Abstract

Distinguishing indolent from clinically significant localized prostate cancer is a major clinical challenge and influences clinical decision-making between treatment and active surveillance. The development of novel predictive biomarkers will help with risk stratification, and clinical decision-making, leading to a decrease in over or under-treatment of patients with prostate cancer. Here, we report that Trop2 is a prognostic tissue biomarker for clinically significant prostate cancer by utilizing the Canary Prostate Cancer Tissue Microarray (CPCTA) cohort composed of over 1100 patients from a multi-institutional study. We demonstrate that elevated Trop2 expression is correlated with worse clinical features including Gleason score, age, and pre-operative PSA levels. More importantly, we demonstrate that elevated Trop2 expression at radical prostatectomy predicts worse overall survival in men undergoing radical prostatectomy. Additionally, we detect shed Trop2 in urine from men with clinically significant prostate cancer. Our study identifies Trop2 as a novel tissue prognostic biomarker and a candidate non-invasive marker for prostate cancer.

Keywords

Male, Humans, Prostatic Neoplasms, Prostate, Prognosis, Prostate-Specific Antigen, Prostatectomy, Biomarkers, Tumor

Comments

Supplementary Materials

PMID: 38177207