Faculty, Staff and Student Publications
Language
English
Publication Date
1-1-2024
Journal
Trauma Surgery & Acute Care Open
DOI
10.1136/tsaco-2023-001193
PMID
38596569
PMCID
PMC11002398
PubMedCentral® Posted Date
April 2024
PubMedCentral® Full Text Version
Post-print
Abstract
OBJECTIVES: Some centers have recommended including concentrated fibrinogen replacement in massive transfusion protocols (MTPs). Given our center's policy of aggressive early balanced resuscitation (1:1:1), beginning prehospital, we hypothesized that our rates of hypofibrinogenemia may be lower than those previously reported.
METHODS: In this retrospective cohort study, patients presenting to our trauma center November 2017 to April 2021 were reviewed. Patients were defined as hypofibrinogenemic (HYPOFIB) if admission fibrinogen
RESULTS: Of 29 782 patients, 6618 level 1 activations, and 1948 patients receiving emergency release blood,
CONCLUSIONS: Low rates of hypofibrinogenemia were found in our center which treats hemorrhage with early, balanced resuscitation. Previously reported higher rates may be partially due to unbalanced resuscitation and/or delay in resuscitation initiation. Routine empiric inclusion of concentrated fibrinogen replacement in MTPs is not supported by the currently available data.
LEVEL OF EVIDENCE: Level III.
Keywords
fibrinogen, wounds and injuries, resuscitation, Shock, Hemorrhagic
Published Open-Access
yes
Recommended Citation
Lubkin, David T; Mueck, Krislynn M; Hatton, Gabrielle E; et al., "Does An Early, Balanced Resuscitation Strategy Reduce The Incidence of Hypofibrinogenemia In Hemorrhagic Shock?" (2024). Faculty, Staff and Student Publications. 2785.
https://digitalcommons.library.tmc.edu/uthmed_docs/2785
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