Faculty, Staff and Student Publications
Language
English
Publication Date
4-9-2025
Journal
Nature Communications
DOI
10.1038/s41467-025-58161-2
PMID
40204694
PMCID
PMC11982547
PubMedCentral® Posted Date
4-9-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Perioperative organ injury contributes to morbidity and mortality of surgical patients. This cohort study included all elective and emergent surgeries in Germany over 4 years to address the impact of perioperative organ injuries on outcomes. We analyzed 28,350,953 cases. In-hospital mortality was 1.4% (n = 393,157), and 4.4% of cases (n = 1,245,898) experienced perioperative organ injury. Perioperative organ injury was associated with 9-fold higher odds of death and prolonged hospital stay by 11.2 days. Acute kidney injury had the highest incidence (2.0%) and was associated with 25.0% mortality. While delirium had the second highest incidence (1.5%), it was associated with the lowest mortality (10.8%). This was followed by acute myocardial infarction (incidence 0.6%, mortality 15.6%), stroke (incidence 0.6%, mortality 13.1%), pulmonary embolism (incidence 0.3%, mortality 20.0%), liver injury (incidence 0.1%, mortality 68.7%), and acute respiratory distress syndrome (incidence 0.1%, mortality 44.7%). These findings help prioritize interventions for preventing or treating individual types of perioperative organ injury.
Keywords
Humans, Male, Female, Middle Aged, Aged, Germany, Hospital Mortality, Acute Kidney Injury, Incidence, Pulmonary Embolism, Length of Stay, Adult, Postoperative Complications, Myocardial Infarction, Cohort Studies, Perioperative Period, Respiratory Distress Syndrome, Stroke, Aged, 80 and over, Surgical Procedures, Operative
Published Open-Access
yes
Recommended Citation
Kork, Felix; Liang, Yafen; Ginde, Adit A; et al., "Impact of Perioperative Organ Injury on Morbidity and Mortality in 28 Million Surgical Patients" (2025). Faculty, Staff and Student Publications. 2799.
https://digitalcommons.library.tmc.edu/uthmed_docs/2799