Faculty, Staff and Student Publications
Activity of Anidulafungin In A Murine Model of Candida Krusei Infection: Evaluation of Mortality and Disease Burden By Quantitative Tissue Cultures and Measurement of Serum (1,3)-Beta-D-Glucan Levels
Publication Date
4-1-2009
Journal
Antimicrobial Agents and Chemotherapy
Abstract
Experience with anidulafungin against Candida krusei is limited. Immunosuppressed mice were injected with 1.3 x 10(7) to 1.5 x 10(7) CFU of C. krusei. Animals were treated with saline, 40 mg/kg fluconazole, 1 mg/kg amphotericin B, or 10 and 20 mg/kg anidulafungin for 5 days. Anidulafungin improved survival and significantly reduced the number of CFU/g in kidneys and serum beta-glucan levels.
Keywords
Animals, Antifungal Agents, Candida, Candidiasis, Disease Models, Animal, Echinocandins, Kidney, Male, Mice, beta-Glucans
DOI
10.1128/AAC.00955-08
PMID
19139291
PMCID
PMC2663062
PubMedCentral® Posted Date
January 2009
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes