Pain Management by Chemogenetic Control of Sensory Neurons

Authors

Yize Li
Xin Ge
Ru-Rong Ji

Language

English

Publication Date

12-19-2023

Journal

Cell Reports Medicine

DOI

10.1016/j.xcrm.2023.101338

PMID

38118411

PMCID

PMC10772549

PubMedCentral® Posted Date

12-19-2023

PubMedCentral® Full Text Version

Post-print

Abstract

In this study, Perez-Sanchez et al.1 developed a chemogenetic method aimed at alleviating pain in mouse models while dampening excitability in human sensory neurons. This analgesic effect was attained through the introduction of human α7 nicotinic acetylcholine receptor and glycine receptor pore domain via virus-mediated expression in sensory neurons, forming a chloride channel. The activation of this channel was made possible by specific agonists. This study highlights the potential for treating clinical pain by gene therapy.

Keywords

Mice, Animals, Humans, Pain Management, Sensory Receptor Cells, Pain, alpha7 Nicotinic Acetylcholine Receptor

Published Open-Access

yes

Recommended Citation

Yize Li, Xin Ge, and Ru-Rong Ji, "Pain Management by Chemogenetic Control of Sensory Neurons" (2023). Faculty, Staff and Student Publications. 3386.
https://digitalcommons.library.tmc.edu/uthmed_docs/3386