Faculty, Staff and Student Publications
Delayed Presentation of a Retained Colonic Segment in a Child With Intestinal Failure on Teduglutide
Language
English
Publication Date
11-1-2025
Journal
JPGN Reports
DOI
10.1002/jpr3.70049
PMID
41245050
PMCID
PMC12611565
PubMedCentral® Posted Date
6-19-2025
PubMedCentral® Full Text Version
Post-print
Abstract
Teduglutide is a glucagon-like peptide 2 (GLP-2) analogue that was approved by the United States Food and Drug Administration for the treatment of pediatric (>1 year) intestinal failure due to short bowel syndrome in 2019. GLP-2 analogues promote rapid intestinal adaptation, increasing the absorptive capacity of residual intestine after surgical resection to aid the achievement of enteral autonomy or reduce parenteral nutrition requirements. Despite relatively few reported side effects, there is a theoretical risk of proliferative complications. Here we present an intriguing case of a pediatric patient found to have a decade-long retained, discontinuous segment of colon from a surgical procedure performed in infancy, which became clinically significant after a period of treatment with teduglutide.
Keywords
enteral autonomy, intestinal adaptation, laparotomy, nutrition, short bowel syndrome
Published Open-Access
yes
Recommended Citation
Bordelon, Rachel C; Varalla, Sarah J; Tammisetti, Varaha S; et al., "Delayed Presentation of a Retained Colonic Segment in a Child With Intestinal Failure on Teduglutide" (2025). Faculty, Staff and Student Publications. 3463.
https://digitalcommons.library.tmc.edu/uthmed_docs/3463