Faculty, Staff and Student Publications

Publication Date

1-1-2025

Journal

Journal of Alzheimer's Disease Reports

DOI

10.1177/25424823251370646

PMID

40861386

PMCID

PMC12371225

PubMedCentral® Posted Date

8-21-2025

PubMedCentral® Full Text Version

Post-print

Abstract

We analyzed how cardiovascular disease subtypes influence the prevalence and incidence of dementia among 30,582 individuals aged 50 and older in the National Alzheimer's Coordinating Center cohort. We calculated prevalence ratios (aPR) and hazard ratios (aHR), using models adjusted for age, sex, race, years of education, hypertension, diabetes, and dyslipidemia. Stroke (aPR: 1.26; 95% CI: 1.20-1.32) and history of arrhythmias (aPR: 1.17; 95% CI: 1.09-1.24) were associated with higher dementia prevalence. In survival analysis, stroke was associated with a 55% increased risk of incident dementia (aHR: 1.55; 95% CI: 1.36-1.77).

Keywords

Alzheimer's disease, cardiovascular diseases, cardiovascular risk factors, cognitive dysfunction, dementia, epidemiology, incidence, longitudinal studies, prevention, stroke

Published Open-Access

yes

Download

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.