Publication Date



Neurobiology of Disease


Early diagnosis of Parkinson's disease (PD) is required to improve therapeutic responses. Indeed, a clinical diagnosis of resting tremor, rigidity, movement and postural deficiencies usually reflect >50% loss of the nigrostriatal system in disease. In a step to address this, quantitative diffusion tensor magnetic resonance imaging (DTI) was used to assess nigrostriatal degeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication model of dopaminergic nigral degeneration. We now demonstrate increased average diffusion (p


Animals, Anisotropy, Brain Mapping, Cell Count, Corpus Striatum, Diffusion, Diffusion Magnetic Resonance Imaging, Disease Models, Animal, Dopamine, Male, Mice, Mice, Inbred C57BL, Nerve Degeneration, Nerve Fibers, Myelinated, Neural Pathways, Neurons, Parkinsonian Disorders, Substantia Nigra



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