Faculty, Staff and Student Publications

Language

English

Publication Date

1-21-2026

Journal

Cancers

DOI

10.3390/cancers18020339

PMID

41595257

PMCID

PMC12839041

PubMedCentral® Posted Date

1-21-2026

PubMedCentral® Full Text Version

Post-print

Abstract

Quiescin sulfhydryl oxidase 1 (QSOX1) is a disulfide bond-forming enzyme with both disulfide isomerase and oxidoreductase activities. It plays an important role in protein folding, stability, and secretion. Growing evidence demonstrates that QSOX1 is upregulated in multiple cancer types and influences key behaviors of cancer cells, including proliferation, migration, invasion, and metastasis. Elevated QSOX1 expression is also associated with tumor malignancy and disease relapse. However, the molecular mechanisms by which QSOX1 drives cancer progression remain incompletely understood. In this review, we summarize current knowledge of QSOX1 expression and regulation in cancer, discuss its functional roles, and highlight key unanswered questions to warrant further investigation.

Keywords

QSOX1, cancer, deregulation, biomarker, therapeutic target

Published Open-Access

yes

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