Faculty, Staff and Student Publications

Language

English

Publication Date

5-7-2025

Journal

International Journal of Molecular Sciences

DOI

10.3390/ijms26094443

PMID

40362681

PMCID

PMC12072545

PubMedCentral® Posted Date

5-7-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Research on the relationship between resistin levels, metabolic health, and obesity has produced inconsistent findings across different ethnic groups, making it unclear whether lower resistin levels are associated with these conditions in Mexican-Americans. This cross-sectional study investigated the relationship between resistin, metabolic health, and obesity in an adult Mexican-American cohort (n = 1511) using multivariable linear regression analysis. Related adipokines (leptin and adiponectin) were measured simultaneously. Participants were categorized into four groups by metabolic health (healthy/unhealthy) and obesity (obese/non-obese) status. “Metabolically unhealthy” was defined as ≥2 cardiometabolic abnormalities. Obesity was defined as a BMI ≥ 30 kg/m2. We also investigated the associations of related proinflammatory cytokines, demographic/anthropometric variables, and medications with each outcome variable of interest. The results showed no statistically significant differences in resistin levels between the groups. Leptin was higher and adiponectin was lower in groups with obesity and/or metabolically unhealthy status. The resistin findings contrast studies in other populations, while other leptin and adiponectin findings confirm those seen in many ethnic groups. Thiazolidinedione use was associated with lower resistin, confirming earlier research. These findings suggest that resistin’s role in metabolic health may be different in Mexican-Americans compared to other populations.

Keywords

Adult, Female, Humans, Male, Middle Aged, Adiponectin, Body Mass Index, Cross-Sectional Studies, Leptin, Mexican Americans, Obesity, Resistin, resistin, leptin, adiponectin, Mexican-American, metabolic health, obesity, IL-1β, IL-6, TNF-α, IL-8

Published Open-Access

yes

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