Faculty, Staff and Student Publications

Language

English

Publication Date

7-22-2025

Journal

Journal of Personalized Medicine

DOI

10.3390/jpm15080327

PMID

40863389

PMCID

PMC12387445

PubMedCentral® Posted Date

7-22-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Barrett's esophagus (BE), a metaplastic transformation of an esophageal squamous epithelium into an intestinal-type columnar epithelium, is the primary precursor to esophageal adenocarcinoma (EAC). Traditional management strategies have relied heavily on selective screening, tailored surveillance intervals, and early dysplasia detection and treatment algorithms. However, the heterogeneity in progression risk among BE patients necessitates a more nuanced, personalized approach involving precision care, tailoring decisions to individual patient characteristics, promises to enhance outcomes in BE through more targeted screening, personalized surveillance intervals, and risk-based therapeutic strategies. This review explores the current landscape and emerging trends in precision medicine for Barrett's esophagus, highlighting genomic markers, digital pathology, and AI-driven models as tools to transform how we approach this complex disease and prevent progression to EAC.

Keywords

precision medicine, Barrett’s esophagus, radiofrequency ablation, cryotherapy, intestinal metaplasia, low-grade dysplasia, high-grade dysplasia

Published Open-Access

yes

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