Circulating Biomarkers in Subjects With Progressive Pulmonary Fibrosis: Data From the Inbuild Trial

Authors

• Toby M Maher
• R Gisli Jenkins
• Francesco Bonella
• Shervin Assassi
• Claudia Diefenbach
• Carina Ittrich
• Klaus B Rohr
• Martin Kolb

Language

English

Publication Date

1-1-2026

Journal

ERJ Open Research

DOI

10.1183/23120541.00158-2025

PMID

41736725

PMCID

PMC12926820

PubMedCentral® Posted Date

2-23-2026

PubMedCentral® Full Text Version

Post-print

Abstract

Background: We investigated the prognostic potential of circulating biomarkers at baseline and the effects of nintedanib on changes in these biomarkers in subjects with progressive pulmonary fibrosis (PPF).

Methods: In the INBUILD trial, subjects with PPF received nintedanib (n=332) or placebo (n=331). Associations between biomarker levels at baseline and the rate of forced vital capacity (FVC) decline (mL·year-1) over 52 weeks, time to interstitial lung disease (ILD) progression (absolute decline in FVC % predicted ≥10%) or death over 52 weeks, time to first acute exacerbation or death over the whole trial, and time to death over the whole trial were assessed in the placebo group. Changes in adjusted mean levels of biomarkers in the nintedanib and placebo groups were assessed using linear mixed models for repeated measures. Biomarker data were log2 transformed prior to analysis. Analyses were corrected for multiplicity.

Results: Baseline level of s-ICAM was significantly associated with rate of FVC decline and time to ILD progression or death over 52 weeks in the placebo group. No biomarker was significantly associated with time to first acute exacerbation or death or time to death. Decreases in Krebs von den Lungen-6 (KL-6), surfactant protein D (SP-D), CA-125 and CA19-9 were observed in subjects who received nintedanib versus placebo over 52 weeks. The largest decrease was in CA-125. In a mediation analysis, 16.4% of the effect of nintedanib on change in FVC at week 52 was attributed to the treatment-related decrease in CA-125 at week 12.

Conclusions: In subjects with PPF, nintedanib reduced circulating CA-125 and, to a lesser extent, other markers of epithelial dysfunction.

Published Open-Access

yes

Recommended Citation

Maher, Toby M; Jenkins, R Gisli; Bonella, Francesco; et al., "Circulating Biomarkers in Subjects With Progressive Pulmonary Fibrosis: Data From the Inbuild Trial" (2026). Faculty, Staff and Student Publications. 3572.
https://digitalcommons.library.tmc.edu/uthmed_docs/3572