Faculty, Staff and Student Publications
Language
English
Publication Date
11-1-2024
Journal
Kidney360
DOI
10.34067/KID.0000000566
PMID
39186376
PMCID
PMC12282638
PubMedCentral® Posted Date
8-26-2024
PubMedCentral® Full Text Version
Post-print
Abstract
Molecular targeted therapy has revolutionized cancer treatment by significantly improving patient survival compared with standard conventional chemotherapies. The use of these drugs targets specific molecules or targets, which block growth and spread of cancer cells. Many of these therapies have been approved for use with remarkable success in breast, blood, colorectal, lung, and ovarian cancers. The advantage over conventional chemotherapy is its ability to deliver drugs effectively with high specificity while being less toxic. Although known as "targeted," many of these agents lack specificity and selectivity, and they tend to inhibit multiple targets, including those in the kidneys. The side effects usually arise because of dysregulation of targets of the inhibited molecule in normal tissue. The off-target effects are caused by drug binding to unintended targets. The on-target effects are associated with inhibition toward the pathway reflecting inappropriate inhibition or activation of the intended drug target. Early detection and correct management of kidney toxicities is crucial to preserve kidney functions. The knowledge of these toxicities helps guide optimal and continued utilization of these potent therapies. This review summarizes the different types of molecular targeted therapies used in the treatment of cancer and the incidence, severity, and pattern of nephrotoxicity caused by them, with their plausible mechanism and proposed treatment recommendations.
Keywords
Humans, Acute Kidney Injury, Antineoplastic Agents, Molecular Targeted Therapy, Neoplasms, Kidney, AKI, albuminuria, BP, chemotherapy, drug nephrotoxicity, hypertension, kidney biopsy, nephrotic syndrome, nitric oxide, proteinuria
Published Open-Access
yes
Recommended Citation
Kala, Jaya; Joseph, Teresa; Pirovano, Marta; et al., "Acute Kidney Injury Associated with Anticancer Therapies: Small Molecules and Targeted Therapies" (2024). Faculty, Staff and Student Publications. 3632.
https://digitalcommons.library.tmc.edu/uthmed_docs/3632