Faculty, Staff and Student Publications
Language
English
Publication Date
7-1-2024
Journal
ACG Case Reports Journal
DOI
10.14309/crj.0000000000001397
PMID
38939351
PMCID
PMC11210963
PubMedCentral® Posted Date
6-27-2024
PubMedCentral® Full Text Version
Post-print
Abstract
Coronavirus disease 2019 (COVID-19) has been associated with liver injury incidence reported between 15% and 53%. Viral binding to ACE2 receptors in hepatobiliary cells is believed to cause liver inflammation. The relationship between hepatitis B and COVID-19 is poorly understood, but patients treated with immunosuppressive therapy for COVID-19 are at higher risk of hepatitis B reactivation (HBVr). We present a case of a patient with HBVr because of COVID-19, in the absence of any immunosuppressive treatment, leading to fulminant liver failure and subsequent requiring liver transplantation. Given low incidence, limited data, and no current guidelines, further studies are needed to evaluate the benefit and cost-effectiveness of anti-HBV prophylaxis in a patient with chronic hepatitis B (CHB) and COVID-19. Meanwhile, the American Association for the Study of Liver Diseases guidelines for patients with CHB and immunosuppressant use can be considered for anti-HBV prophylaxis for patients with CHB and COVID-19 to prevent HBVr on a case-by-case basis.
Keywords
hepatitis B reactivation, COVID-19, liver failure
Published Open-Access
yes
Recommended Citation
Muhammad Mushtaq, Keegan Colletier, and Akshata Moghe, "Hepatitis B Reactivation and Liver Failure Because of COVID-19 Infection" (2024). Faculty, Staff and Student Publications. 3663.
https://digitalcommons.library.tmc.edu/uthmed_docs/3663