Faculty, Staff and Student Publications

Language

English

Publication Date

5-1-2026

Journal

Arthritis Care & Research

DOI

10.1002/acr.25658

PMID

41098036

PMCID

PMC13116043

PubMedCentral® Posted Date

12-26-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Objective: Ultrasound (US) has been proposed as a potential tool for assessing skin fibrosis in systemic sclerosis (SSc). However, a large-scale comparison of US-based assessment with histologic markers of skin fibrosis has not been reported. We evaluated US-based skin assessments for their face validity (differentiation between involved SSc and healthy control [HC] skin), construct validity (comparison to modified Rodnan skin score [mRSS]), and criterion validity (comparison to histologic and gene expression fibrosis markers).

Methods: Twenty HCs and 52 patients with SSc underwent clinical and US assessment followed by a forearm skin biopsy. Predefined areas were assessed on the finger, hand, and forearm bilaterally. mRSS, US, histologic and molecular (reverse transcription quantitative polymerase chain reaction) evaluations were performed by blinded, independent assessors. Dermal thickness, echogenicity, and elastography were assessed using a high-frequency GE LOGIQ P9 US machine.

Results: Except in the hand area, the US variables could not differentiate between HC and clinically affected SSc skin (face validity). There was only a weak to moderate correlation between US-based measurements and mRSS in the hand and finger areas (construct validity). US-based thickness showed moderate correlation with histologic thickness (ρ = 0.43; P = 0.002) but no statistically significant correlations with other histologic or gene expression markers of fibrosis in patients with SSc (criterion validity).

Conclusion: High-frequency US assessment of SSc skin does not show consistent and strong face, construct, or criterion validity. The role of this assessment tool remains limited, underscoring the need for further development of a quantitative and accurate tool for assessing SSc skin fibrosis.

Keywords

Humans, Elasticity Imaging Techniques, Scleroderma, Systemic, Middle Aged, Skin, Female, Male, Adult, Aged, Fibrosis, Reproducibility of Results, Biopsy, Ultrasonography

Published Open-Access

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