Artificial Gravity: An Effective Countermeasure for Microgravity-Induced Headward Fluid Shift?

Authors

• Larry A Kramer
• Khader M Hasan
• Xu Zhang
• Edwin Mulder
• Darius A Gerlach
• Karina Marshall-Goebel
• Brandon R Macias
• Steven S Laurie
• Gary Strangman
• Raj Iyer
• Eric M Bershad

Language

English

Publication Date

11-1-2024

Journal

Journal of Applied Physiology

DOI

10.1152/japplphysiol.00441.2024

PMID

39262341

PMCID

PMC11563643

PubMedCentral® Posted Date

9-12-2024

PubMedCentral® Full Text Version

Post-print

Abstract

Long-duration spaceflight is associated with pathophysiological changes in the intracranial compartment hypothetically linked to microgravity-induced headward fluid shift. This study aimed to determine whether daily artificial gravity (AG) sessions can mitigate these effects, supporting its application as a countermeasure to spaceflight. Twenty-four healthy adult volunteers (16 men) were exposed to 60 days of 6° head-down tilt bed rest (HDTBR) as a ground-based analog of chronic headward fluid shift. Subjects were divided equally into three groups: no AG (control), daily 30-min intermittent AG (iAG), and daily 30-min continuous (cAG). Internal carotid artery (ICA) stroke volume (ICASV), ICA resistive index (ICARI), ICA flow rate (ICAFR), aqueductal cerebral spinal fluid flow velocity (CSFV), and intracranial volumetrics were quantified at 3 T. MRI was performed at baseline, 14 and 52 days into HDTBR, and 3 days after HDTBR (recovery). A mixed model approach was used with intervention and time as the fixed effect factors and the subject as the random effect factor. Compared with baseline, HDTBR was characterized by expansion of lateral ventricular, white matter, gray matter, and brain + total intracranial cerebral spinal fluid volumes, increased CSFv, decreased ICASV, and decreased ICAFR by 52 days into HBTBR (All Ps < 0.05). ICARI was only increased 14 days into HDTBR (P < 0.05). Neither iAG nor cAG significantly affected measurements compared with HDTBR alone, indicating that 30 min of daily exposure was insufficient to mitigate the intracranial effects of headward fluid shift. Greater AG session exposure time, gravitational force, or both are suggested for future countermeasure research.

NEW & NOTEWORTHY Brief exposure to continuous or intermittent artificial gravity via short-arm centrifugation was insufficient in mitigating the intracranial pathophysiological effects of the headward fluid shift simulated during head-down tilt bed rest (HDTBR). Our results suggest that greater centrifugation session duration, gravitational force, or both may be required to prevent the development of spaceflight-associated neuro-ocular syndrome and should be considered in future ground-based countermeasure studies.

Keywords

Humans, Male, Gravity, Altered, Adult, Female, Head-Down Tilt, Fluid Shifts, Weightlessness, Bed Rest, Space Flight, Weightlessness Countermeasures, Cerebrovascular Circulation, Young Adult, Brain, artificial gravity, head-down tilt bedrest, microgravity, MRI, spaceflight-associated neuro-ocular syndrome

Published Open-Access

yes

Recommended Citation

Kramer, Larry A; Hasan, Khader M; Zhang, Xu; et al., "Artificial Gravity: An Effective Countermeasure for Microgravity-Induced Headward Fluid Shift?" (2024). Faculty, Staff and Student Publications. 3708.
https://digitalcommons.library.tmc.edu/uthmed_docs/3708