Faculty, Staff and Student Publications
Language
English
Publication Date
12-26-2024
Journal
Current Neurology and Neuroscience Reports
DOI
10.1007/s11910-024-01396-1
PMID
39722093
PMCID
PMC13081737
PubMedCentral® Posted Date
4-16-2026
PubMedCentral® Full Text Version
Author MSS
Abstract
Purpose of review: Early brain injury (EBI) after aneurysmal subarachnoid hemorrhage (SAH) is the most influential clinical determinant of outcomes. Despite significant advances in understanding of the pathophysiology of EBI, currently no treatments to target EBI have been developed. This review summarizes recent advances in EBI research over the past five years with a focus on potential therapeutic targets.
Recent findings: Mechanism-specific translational studies are converging on several pathophysiologic pathways: improved antioxidant delivery and the Sirt1/Nrf2 pathway for reactive oxygen species; NLRP3 inflammasome and microglial polarization for inflammation; and the PI3K/Akt pathway for apoptosis. Recently identified mechanistic components, such as microcirculatory failure and ferroptosis, need particular attention. Clinical studies developing radiographic markers and mechanism-specific, biofluid markers are attempting to bridge the translational therapeutic gap. There has been an exponential growth in EBI research. Further clinical studies which address specific pathophysiology mechanisms need to be performed to identify novel therapeutic approaches.
Keywords
Humans, Subarachnoid Hemorrhage, Brain Injuries, Animals, Early brain injury, Subarachnoid hemorrhage, Pathophysiology, Biomarkers, Translational research
Published Open-Access
yes
Recommended Citation
Yang, Bosco Seong Kyu; Gusdon, Aaron M; Ren, Xuefang Sophie; et al., "Update on Strategies To Reduce Early Brain Injury After Subarachnoid Hemorrhage" (2024). Faculty, Staff and Student Publications. 3759.
https://digitalcommons.library.tmc.edu/uthmed_docs/3759