Faculty, Staff and Student Publications

Language

English

Publication Date

12-17-2025

Journal

Journal of NeuroInterventional Surgery

DOI

10.1136/jnis-2024-022642

PMID

39855674

PMCID

PMC12284089

PubMedCentral® Posted Date

7-23-2025

PubMedCentral® Full Text Version

Author MSS

Abstract

Background: Current randomized controlled trials are investigating the efficacy and safety of mechanical thrombectomy (MT) in patients with medium vessel occlusion (MeVO) stroke. Whether best medical management (MM) is more efficient than unsuccessful vessel recanalization during MT remains unknown.

Methods: This was a retrospective cohort study using data from 37 academic centers across North America, Asia, and Europe between September 2017 and July 2021. Only patients with occlusion of the distal branches (M2 and M3) of the middle cerebral artery territory were included. Unsuccessful MT was defined as a modified Thrombolysis in Cerebral Infarction score of 0-2a. Propensity score matching was used to control for confounders. The primary outcome was functional independence, defined as a modified Rankin Scale (mRS) score of 0-2 at 90 days after treatment. Multivariable regression analysis was used to assess factors associated with the primary outcome.

Results: Of 2903 patients screened for eligibility, 532 patients were analyzed (266 per group) after propensity score matching. The MM group had superior functional outcomes, with 32% achieving mRS 0-1 at 90 days compared with 21% in the MT group (P=0.011). Patients in the MM group also had significantly lower rates of symptomatic intracranial hemorrhage (sICH) (3.4% vs 16%, P< 0.001) and any hemorrhage (18% vs 48%, P< 0.001). On multivariable regression, unsuccessful MT was associated with reduced odds of functional independence (OR 0.50, 95% CI 0.29 to 0.85, P=0.011) and increased odds of sICH (OR 4.32, 95% CI 1.84 to 10.10, P< 0.001). Mortality rates were similar between groups (27% in MM vs 29% in MT, P=0.73).

Conclusion: Unsuccessful MT for MeVO was linked to worse outcomes than best MM. These findings highlight the risks of prolonged attempts and emphasize the importance of efficient procedural decision-making to reduce complications and improve patient outcomes.

Keywords

Humans, Male, Retrospective Studies, Female, Aged, Thrombectomy, Middle Aged, Infarction, Middle Cerebral Artery, Treatment Outcome, Cohort Studies, Aged, 80 and over, Mechanical Thrombectomy (MT), Medium Vessel Occlusion (MeVO), Stroke

Published Open-Access

yes

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