Faculty, Staff and Student Publications

Language

English

Publication Date

8-1-2025

Journal

Movement Disorders Clinical Practice

DOI

10.1002/mdc3.70058

PMID

40172482

PMCID

PMC12371435

PubMedCentral® Posted Date

4-2-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Background: The diagnostic value of midbrain atrophy for distinguishing behavioral variant frontotemporal dementia (bvFTD) from progressive supranuclear palsy (PSP) is unclear.

Objective: To investigate whether measures of midbrain atrophy differentiate PSP from bvFTD.

Methods: We included four groups: healthy controls (n = 19), PSP-Richardson syndrome (n = 20), bvFTD (n = 19) and Parkinson's disease (PD; n = 12). The following quantitative and qualitative measures were calculated: Hummingbird sign rating scale [HBS-RS], global midbrain atrophy [GMA], midbrain area, midbrain/pons ratio, the Magnetic Resonance Parkinsonism Index (MRPI), the MRPI 2.0 and brainstem volume.

Results: Compared to controls, PSP and bvFTD had lower values of midbrain area, HBS-RS and GMA, and higher MRPI and MRPI 2.0. HBS-RS, GMA, midbrain/pons ratio, midbrain area, MRPI, MRPI 2.0 and brainstem volume distinguished PSP from bvFTD with 73%, 67%, 75%, 83%, 71%, 69% and 82% accuracies, respectively.

Conclusions: Both quantitative and qualitative measures of midbrain atrophy provided modest accuracy in distinguishing PSP from bvFTD.

Keywords

Humans, Supranuclear Palsy, Progressive, Frontotemporal Dementia, Mesencephalon, Atrophy, Male, Aged, Female, Magnetic Resonance Imaging, Middle Aged, Diagnosis, Differential, Parkinson Disease, progressive supranuclear palsy, frontotemporal dementia, parkinsonism, neuroimaging, midbrain atrophy

Published Open-Access

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