Publication Date
10-24-2017
Journal
Neurology
Abstract
OBJECTIVE: To determine whether common variants in familial cerebral small vessel disease (SVD) genes confer risk of sporadic cerebral SVD.
METHODS: We meta-analyzed genotype data from individuals of European ancestry to determine associations of common single nucleotide polymorphisms (SNPs) in 6 familial cerebral SVD genes (
RESULTS: A locus in
CONCLUSIONS: These results provide evidence of shared genetic determinants and suggest common pathophysiologic mechanisms of distinct ischemic and hemorrhagic cerebral SVD stroke phenotypes, offering new insights into the causal mechanisms of cerebral SVD.
Keywords
Cerebral Hemorrhage, Collagen Type IV, Europe, Genetic Association Studies, Humans, Polymorphism, Single Nucleotide, Stroke, Lacunar