COL4A2 Is Associated With Lacunar Ischemic Stroke and Deep Ich: Meta-Analyses Among 21,500 Cases and 40,600 Controls

Authors

Kristiina Rannikmäe
Vhinoth Sivakumaran
Henry Millar
Rainer Malik
Christopher D Anderson
Mike Chong
Tushar Dave
Guido J Falcone
Israel Fernandez-Cadenas
Jordi Jimenez-Conde
Arne Lindgren
Joan Montaner
Martin O'Donnell
Guillaume Paré
Farid Radmanesh
Natalia S Rost
Agnieszka Slowik
Martin Söderholm
Matthew Traylor
Sara L Pulit
Sudha Seshadri
Brad B Worrall
Daniel Woo
Hugh S Markus
Braxton D Mitchell
Martin Dichgans
Jonathan Rosand
Cathie L M Sudlow

Language

English

Publication Date

10-24-2017

Journal

Neurology

DOI

10.1212/WNL.0000000000004560

PMID

28954878

PMCID

PMC5664302

PubMedCentral® Posted Date

October 2017

PubMedCentral® Full Text Version

Post-print

Abstract

OBJECTIVE: To determine whether common variants in familial cerebral small vessel disease (SVD) genes confer risk of sporadic cerebral SVD.

METHODS: We meta-analyzed genotype data from individuals of European ancestry to determine associations of common single nucleotide polymorphisms (SNPs) in 6 familial cerebral SVD genes (

RESULTS: A locus in

CONCLUSIONS: These results provide evidence of shared genetic determinants and suggest common pathophysiologic mechanisms of distinct ischemic and hemorrhagic cerebral SVD stroke phenotypes, offering new insights into the causal mechanisms of cerebral SVD.

Keywords

Cerebral Hemorrhage, Collagen Type IV, Europe, Genetic Association Studies, Humans, Polymorphism, Single Nucleotide, Stroke, Lacunar

Published Open-Access

yes

Recommended Citation

Rannikmäe, Kristiina; Sivakumaran, Vhinoth; Millar, Henry; et al., "COL4A2 Is Associated With Lacunar Ischemic Stroke and Deep Ich: Meta-Analyses Among 21,500 Cases and 40,600 Controls" (2017). Faculty, Staff and Student Publications. 382.
https://digitalcommons.library.tmc.edu/uthmed_docs/382