Faculty, Staff and Student Publications

Language

English

Publication Date

1-1-2026

Journal

PLoS One

DOI

10.1371/journal.pone.0337000

PMID

41996317

PMCID

PMC13089703

PubMedCentral® Posted Date

4-17-2026

PubMedCentral® Full Text Version

Post-print

Abstract

INTRODUCTION: Hemangioblastomas (HGB) are the most common primary intra-axial tumors in the posterior fossa in adults, with an overall occurrence of 7-10%. They occur sporadically or as part of von Hippel-Lindau (VHL) disease. The role of stereotactic radiosurgery (SRS) as a minimally invasive treatment in larger HGB (>2cc) has not been thoroughly investigated.

METHODS: This multi-center study retrospectively analyzed data from 91 patients with large HGB (>2cc) treated between 1993 and 2023. Patients were stratified into VHL-associated and sporadic groups, with assessments including radiosurgical parameters, tumor response, overall survival (OS), and progression-free survival (PFS).

RESULTS: Patients with VHL-associated HGB were younger at diagnosis (median: 33 years vs. 52 years, p <  0.001) and presented more frequently with multiple tumors (68.8% vs. 23.2%, p <  0.001). Cerebellar lesions were the most common location (70%), followed by brainstem lesions (21%). The median target tumor volume was smaller in VHL cases (3.49 cc vs. 6.5 cc, p = 0.038). Tumor control was achieved in 70% of cases across groups, with no significant differences in outcomes between VHL and sporadic cases. OS (170 months for VHL and 199 months for sporadic cases) and PFS (108 months for both groups) were comparable. Radiation necrosis was observed in 8.8% of patients.

CONCLUSIONS: SRS may provide favorable tumor control with low morbidity in both VHL-associated and sporadic cases of larger HGB (>2 cc).Future studies should compare SRS with resection for larger HGB and explore molecular predictors of favorable response to SRS.

Keywords

Humans, Hemangioblastoma, Radiosurgery, Adult, Female, Male, Middle Aged, Retrospective Studies, von Hippel-Lindau Disease, Young Adult, Aged, Treatment Outcome, Cerebellar Neoplasms, Adolescent, Progression-Free Survival

Published Open-Access

yes

Download

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.