Faculty, Staff and Student Publications
Publication Date
10-1-2023
Journal
Endocrinology and Metabolism
DOI
10.3803/EnM.2023.1813
PMID
37816498
PMCID
PMC10613775
PubMedCentral® Posted Date
10-10-2023
PubMedCentral® Full Text Version
Post-print
Abstract
The growing recognition of mitochondria's crucial role in the regulation of white adipose tissue remodeling and energy balance underscores its significance. The marked metabolic diversity of mitochondria provides the molecular and cellular foundation for enabling adipose tissue plasticity in response to various metabolic cues. Effective control of mitochondrial function at the cellular level, not only in thermogenic brown and beige adipocytes but also in energy-storing white adipocytes, exerts a profound influence on adipose homeostasis. Furthermore, mitochondria play a pivotal role in intercellular communication within adipose tissue via production of metabolites with signaling properties. A more comprehensive understanding of mitochondrial regulation within white adipocytes will empower the development of targeted and efficacious strategies to enhance adipose function, leading to advancements in overall metabolic health.
Keywords
Humans, Adipocytes, White, Adipose Tissue, Signal Transduction, Mitochondria, Thermogenesis, Obesity, White adipocyte, Mitochondria, Adipose tissue remodeling, Metabolic health, Signaling metabolite
Published Open-Access
yes
Recommended Citation
Juan Cai, Fenfen Wang, and Mengle Shao, "The Emerging Importance of Mitochondria in White Adipocytes: Neither Last nor Least" (2023). Faculty, Staff and Student Publications. 3927.
https://digitalcommons.library.tmc.edu/uthmed_docs/3927