Faculty, Staff and Student Publications

Language

English

Publication Date

3-5-2026

Journal

BMJ Case Reports

DOI

10.1136/bcr-2025-269690

PMID

41786442

PMCID

PMC12969776

PubMedCentral® Posted Date

3-5-2026

PubMedCentral® Full Text Version

Post-print

Abstract

This report describes a female patient in her 60s with an immune-mediated necrotising myopathy (IMNM) occurring after semaglutide use. She was found to have progressive dysphagia, dysphonia, proximal muscle weakness and creatine kinase elevation over a 4-month course. Her symptoms were preceded by a single dose of semaglutide. Her work-up revealed features consistent with necrotising myopathy with inflammatory infiltrate on biopsy, and she responded to immunosuppression with corticosteroids and intravenous immunoglobulin (IVIG). She gradually improved and successfully returned to her baseline functional status while off immunosuppression for several months and with continued avoidance of glucagon-like peptide-1 (GLP-1) receptor agonists. Here, we describe the first reported case of IMNM probably associated with GLP-1 receptor agonist use, with apparent response to a short course of immunosuppression and IVIG.

Keywords

Humans, Female, Glucagon-Like Peptides, Immunoglobulins, Intravenous, Middle Aged, Muscular Diseases, Necrosis, Hypoglycemic Agents, Musculoskeletal syndromes, Connective tissue disease, Drugs: endocrine system, Immunology, Muscle disease

Published Open-Access

yes

Download

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.