Faculty, Staff and Student Publications

Language

English

Publication Date

1-1-2024

Journal

Case Reports in Infectious Diseases

DOI

10.1155/crdi/4459447

PMID

39619279

PMCID

PMC11606694

PubMedCentral® Posted Date

11-20-2024

PubMedCentral® Full Text Version

Post-print

Abstract

We report a case of a 15-year-old with refractory and relapsed AML and profound prolonged neutropenia who developed a Saprochaete capitata disseminated invasive infection while on echinocandin prophylaxis for invasive fungal disease. Azole antifungal therapies, which are often used as prophylaxis, were initially avoided due to concerns for CYP drug interactions. Treatment with a combination of liposomal amphotericin B, voriconazole, and adjuvant granulocyte transfusions was successful as he awaited neutrophil recovery.

Keywords

AML, echinocandin resistance, Saprochaete capitata

Published Open-Access

yes

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