Faculty, Staff and Student Publications

Language

English

Publication Date

7-3-2025

Journal

International Journal of Molecular Sciences

DOI

10.3390/ijms26136416

PMID

40650193

PMCID

PMC12250488

PubMedCentral® Posted Date

7-3-2025

PubMedCentral® Full Text Version

Post-print

Abstract

Parkinson's disease (PD) is considered the second most common neurodegenerative disease worldwide; treating this disease remains quite challenging. Environmental and genetic factors may play a role in the pathophysiology of PD. α-synuclein aggregation, oxidative stress, ferroptosis, mitochondrial failure, neuroinflammation, and gut dysbiosis are among the known risk factors of PD. The pathophysiology of Parkinson's disease is complicated by the interconnections between these molecular pathways, which also present significant obstacles to treatment development. However, due to its complex mechanism and long latency, PD is difficult to diagnose and detect, which presents a barrier to treatment. In addition, the need to develop new treatments for PD is increased by the fact that the majority of traditional therapeutic methods have major side effects and limited effects. Therefore, a deeper understanding of the fundamental mechanisms underlying PD is required. This review provides a comprehensive analysis of the current landscape of PD pathophysiology, paying particular attention to the molecular processes of PD, as well as the traditional research models, clinical diagnostic standards, documented medication therapeutic approaches, and recently disclosed drug candidates in clinical trials. We also highlighted the herbal-derived components that have recently been identified for their effects in the treatment of PD to provide a review and perspectives for the development of the next generation of drugs and preparations for the treatment of PD.

Keywords

Parkinson’s disease (PD), oxidative stress, ferroptosis, mitochondrial dysfunction, neuroinflammation, gut dysbiosis, medicinal plants

Published Open-Access

yes

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