Faculty, Staff and Student Publications

Language

English

Publication Date

8-20-2024

Journal

Diagnostics

DOI

10.3390/diagnostics14161814

PMID

39202302

PMCID

PMC11354199

PubMedCentral® Posted Date

8-20-2024

PubMedCentral® Full Text Version

Post-print

Abstract

Primary Ciliary Dyskinesia (PCD) is a rare genetic disorder characterized by alterations in motile cilia function. The diagnosis of PCD is challenging due to the lack of standardized methods in clinical practice. High-speed video microscopy analysis (HSVA) directly evaluates ciliary beat frequency (CBF) in PCD. Recently, open-source ciliary analysis software applications have shown promise in measuring CBF accurately. However, there is limited knowledge about the performance of different software applications, creating a gap in understanding their comparative effectiveness in measuring CBF in PCD. We compared two open-source software applications, CiliarMove (v219) and Cilialyzer (v1.2.1-b3098cb), against the manual count method. We used high-speed videos of nasal ciliary brush samples from PCD

Keywords

primary ciliary dyskinesia, ciliary beat frequency, high-speed video microscopy analysis, Cilialyzer, CiliarMove

Published Open-Access

yes

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