Faculty, Staff and Student Publications
Language
English
Publication Date
11-1-2023
Journal
Science China Life Sciences
DOI
10.1007/s11427-022-2308-8
PMID
37258801
PMCID
PMC11057326
PubMedCentral® Posted Date
4-29-2024
PubMedCentral® Full Text Version
Author MSS
Abstract
This study presents a novel compound muscle action potential (CMAP) examination of motor unit changes in paretic muscle post stroke. CMAP scan of the first dorsal interosseous (FDI) muscle was performed bilaterally in 16 chronic stroke subjects. Various parameters were derived from the CMAP scan to examine paretic muscle changes, including CMAP amplitude, D50, step index (STEPIX) and amplitude index (AMPIX). A significant decrease in CMAP amplitude and STEPIX was observed in paretic muscles compared with contralateral muscles (CMAP amplitude: paretic (9.0±0.5) mV, contralateral (11.3±0.9) mV, P=0.024; STEPIX: paretic 101.2±7.6, contralateral 121.9±6.5, P=0.020). No significant difference in D50 and AMPIX was observed between the paretic and contralateral sides (P>0.05). The findings revealed complex paretic muscle changes including motor unit degeneration, muscle fiber denervation, reinnervation and atrophy, providing useful insights to help understand neuromuscular mechanisms associated with weakness and other functional deterioration post stroke. The CMAP scan experimental protocols and the applied processing methods are noninvasive, convenient, and automated, offering practical benefits for clinical application.
Keywords
Humans, Muscle, Skeletal, Electromyography, Action Potentials, Stroke
Published Open-Access
yes
Recommended Citation
Chen, Maoqi; Lu, Zhiyuan; Li, Xiaoyan; et al., "Compound Muscle Action Potential (Cmap) Scan Examination of Paretic and Contralateral Muscles Reveals Motor Unit Alterations After Stroke" (2023). Faculty, Staff and Student Publications. 4315.
https://digitalcommons.library.tmc.edu/uthmed_docs/4315
Comments
This article has been corrected. See Sci China Life Sci. 2023 Aug 25.