Gonadotropin-Dependent Precocious Puberty: Single-Center Experience From Western India

Authors

• Aditya Phadte
• Vijaya Sarathi
• Sweta Budyal
• Anurag Lila
• Saba Samad Memon
• Manjiri Karlekar
• Virendra Patil
• Nalini Shah
• Tushar Bandgar

Language

English

Publication Date

6-15-2023

Journal

Indian Pediatrics

PMID

37211886

Abstract

Objective: To describe the characteristics of gonadotropin-dependent precocious puberty (GDPP) in Indian children.

Methods: Clinical profiles of GDPP (n=78, 61 females) and premature thelarche (n=12) from a single center in Western India were retrospectively studied.

Results: Pubertal onset was earlier in boys than girls (29 vs 75 months, respec-tively; P=0.008). The basal luteinizing hormone (LH) was ≥0.3 mIU/mL, except 18% of GDPP girls. At 60 minutes after GnRHa-stimulation, all patients (except one girl) had LH ≥5 mIU/mL. The GnRHa-stimulated LH/FSH ratio was ≥0.34 at 60 minutes in girls with GDPP unlike premature thelarche. Only one girl had an allergic reaction to long-acting GnRH agonist. Among GnRH agonist-treated girls (n=24), the predicted final adult height was -1.67±1.5 SDS, whereas the attained final height was -0.25±1.48 SDS.

Conclusion: We establish the safety and efficacy of long acting GnRH agonist therapy in Indian children with GDPP. The 60-minute stimulated serum LH/FSH of ≥0.34 differentiated GDPP from premature thelarche.

Keywords

Child, Female, Male, Adult, Humans, Puberty, Precocious, Gonadotropin-Releasing Hormone, Follicle Stimulating Hormone, Retrospective Studies, Luteinizing Hormone, Puberty

Published Open-Access

yes

Recommended Citation

Phadte, Aditya; Sarathi, Vijaya; Budyal, Sweta; et al., "Gonadotropin-Dependent Precocious Puberty: Single-Center Experience From Western India" (2023). Faculty, Staff and Student Publications. 4322.
https://digitalcommons.library.tmc.edu/uthmed_docs/4322