The Toxicology Investigators Consortium 2023 Annual Report

Authors

• Adrienne Hughes
• Alexandra Amaducci
• Sharan L Campleman
• Shao Li
• Mari Costantini
• Meghan B Spyres
• Hannah Spungen
• Jessica Kent
• Alyssa Falise
• Rachel Culbreth
• Paul M Wax
• Jeffery Brent
• Kim Aldy
• Toxicology Investigators Consortium Study Group

Language

English

Publication Date

10-1-2024

Journal

Journal of Medical Toxicology

DOI

10.1007/s13181-024-01033-w

PMID

39256327

PMCID

PMC11436580

PubMedCentral® Posted Date

9-10-2024

PubMedCentral® Full Text Version

Post-print

Abstract

Since 2010, the American College of Medical Toxicology (ACMT) Toxicology Investigators Consortium (ToxIC) has maintained the ToxIC Core Registry, a national case registry of in-hospital and clinic patient consultations submitted by medical toxicology physicians. Deidentified patient data entered into the registry includes patient demographics, reason for medical toxicology evaluation, exposure agents, clinical signs and symptoms, treatments and antidotes administered, and mortality. This fourteenth annual report provides data from 7392 patients entered into the Core Registry in 2023 by 36 participating sites comprising 61 distinct healthcare facilities, bringing the total case count to 102331 between 2010 and 2023. Ethanol was the most commonly reported exposure agent class (24.4%), followed by opioids (22.7%), non-opioid analgesics (16.7%), and antidepressants (11.7%). For the first time since the registry's initiation, in 2023, ethanol was the leading agent of exposure. There were 98 fatalities (case fatality rate of 1.3%). Additional descriptive analyses in this annual report were conducted to describe the reasons for medical toxicology consultation by age in 2023, and yearly trends for opioid and psychoactive exposures, physostigmine and rivastigmine treatments, and acetaminophen exposures treated with fomepizole.

Keywords

Humans, Male, Adult, Middle Aged, Female, Registries, Adolescent, Aged, Toxicology, Young Adult, Poisoning, Child, United States, Child, Preschool, Infant, Antidotes, Aged, 80 and over, Poisoning, Overdose, Surveillance, Epidemiology, Medical Toxicology

Published Open-Access

yes

Recommended Citation

Hughes, Adrienne; Amaducci, Alexandra; Campleman, Sharan L; et al., "The Toxicology Investigators Consortium 2023 Annual Report" (2024). Faculty, Staff and Student Publications. 4435.
https://digitalcommons.library.tmc.edu/uthmed_docs/4435