Faculty, Staff and Student Publications

Language

English

Publication Date

11-1-2024

Journal

Neuroimage

DOI

10.1016/j.neuroimage.2024.120866

PMID

39322095

PMCID

PMC11682661

PubMedCentral® Posted Date

12-29-2024

PubMedCentral® Full Text Version

Author MSS

Abstract

Corticostriatal connections are essential for motivation, cognition, and behavioral flexibility. There is broad interest in using resting-state functional magnetic resonance imaging (rs-fMRI) to link circuit dysfunction in these connections with neuropsychiatric disorders. In this paper, we used tract-tracing data from non-human primates (NHPs) to assess the likelihood of monosynaptic connections being represented in rs-fMRI data of NHPs and humans. We also demonstrated that existing hub locations in the anatomical data can be identified in the rs-fMRI data from both species. To characterize this in detail, we mapped the complete striatal projection zones from 27 tract-tracer injections located in the orbitofrontal cortex (OFC), dorsal anterior cingulate cortex (dACC), ventromedial prefrontal cortex (vmPFC), ventrolateral PFC (vlPFC), and dorsal PFC (dPFC) of macaque monkeys. Rs-fMRI seeds at the same regions of NHP and homologous regions of human brains showed connectivity maps in the striatum mostly consistent with those observed in the tracer data. We then examined the location of overlap in striatal projection zones. The medial rostral dorsal caudate connected with all five frontocortical regions evaluated in this study in both modalities (tract-tracing and rs-fMRI) and species (NHP and human). Other locations in the caudate also presented an overlap of four frontocortical regions, suggesting the existence of different locations with lower levels of input diversity. Small retrograde tracer injections and rs-fMRI seeds in the striatum confirmed these cortical input patterns. This study sets the ground for future studies evaluating rs-fMRI in clinical samples to measure anatomical corticostriatal circuit dysfunction and identify connectional hubs to provide more specific treatment targets for neurological and psychiatric disorders.

Keywords

Magnetic Resonance Imaging, Animals, Humans, Corpus Striatum, Male, Neural Pathways, Macaca mulatta, Prefrontal Cortex, Female, Species Specificity, Brain Mapping, Connectome, Nerve Net, Adult, Striatal hub, Cross-species, Tract tracing, Functional connectivity, fMRI

Published Open-Access

yes

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