Faculty, Staff and Student Publications

Language

English

Publication Date

6-1-2025

Journal

The American Journal of Surgery

DOI

10.1016/j.amjsurg.2024.116106

PMID

39615438

PMCID

PMC12085301

PubMedCentral® Posted Date

6-1-2026

PubMedCentral® Full Text Version

Author MSS

Abstract

Background: The relationship between inflammatory biomarkers (IB) and organ space surgical site infections (OS-SSIs) after emergency laparotomy (EL) is poorly understood.

Methods: Retrospective, single-center analysis of patients in the Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR) trial who underwent EL and survived 48 h after admission was performed. IB levels of IL-6, IL-8, G-CSF, MCP-1, neutrophil to lymphocyte ratio, and platelet to lymphocyte ratio were analyzed. IB and OS-SSIs association was evaluated using the Wilcoxon rank sum test.

Results: Of 74 eligible patients, 80 % were male, 69 % sustained blunt trauma, the injury severity score was 31 (24-41), and 22 % developed OS-SSIs. Levels of IL-6 (12, 24 h), IL-8 (2, 12, 24, 72 h), and MCP-1 (24 h) were higher in OS-SSI patients (P < 0.05).

Conclusions: IL-6, IL-8, and MCP-1 levels were associated with OS-SSIs in PROPPR patients who underwent EL. The IB may help to predict high-risk patients for OS-SSIs.

Keywords

Humans, Male, Female, Biomarkers, Retrospective Studies, Adult, Laparotomy, Surgical Wound Infection, Middle Aged, Chemokine CCL2, Interleukin-8, Interleukin-6, Blood Transfusion, Injury Severity Score, Emergencies

Published Open-Access

yes

Download

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.