Adenosine Metabolized From Extracellular ATP Promotes Type 2 Immunity Through Triggering A2BAR Signaling in Intestinal Epithelial Cells

Authors

Darine W El-Naccache
Fei Chen
Mark J Palma
Alexander Lemenze
Matthew A Fischer
Wenhui Wu
Pankaj K Mishra
Holger K Eltzschig
Simon C Robson
Francesco Di Virgilio
George S Yap
Karen L Edelblum
György Haskó
William C Gause

Language

English

Publication Date

8-2-2022

Journal

Cell Reports

DOI

10.1016/j.celrep.2022.111150

PMID

35926464

PMCID

PMC9402265

PubMedCentral® Posted Date

August 2022

PubMedCentral® Full Text Version

Post-print

Abstract

Intestinal nematode parasites can cross the epithelial barrier, causing tissue damage and release of danger-associated molecular patterns (DAMPs) that may promote host protective type 2 immunity. We investigate whether adenosine binding to the A

Keywords

Adenosine, Adenosine Triphosphate, Animals, Epithelial Cells, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptor, Adenosine A2B

Published Open-Access

yes

Recommended Citation

El-Naccache, Darine W; Chen, Fei; Palma, Mark J; et al., "Adenosine Metabolized From Extracellular ATP Promotes Type 2 Immunity Through Triggering A2BAR Signaling in Intestinal Epithelial Cells" (2022). Faculty, Staff and Student Publications. 462.
https://digitalcommons.library.tmc.edu/uthmed_docs/462