Adenosine metabolized from extracellular ATP promotes type 2 immunity through triggering A

Authors

Darine W El-Naccache
Fei Chen
Mark J Palma
Alexander Lemenze
Matthew A Fischer
Wenhui Wu
Pankaj K Mishra
Holger K Eltzschig
Simon C Robson
Francesco Di Virgilio
George S Yap
Karen L Edelblum
György Haskó
William C Gause

Publication Date

8-2-2022

Journal

Cell Reports

Abstract

Intestinal nematode parasites can cross the epithelial barrier, causing tissue damage and release of danger-associated molecular patterns (DAMPs) that may promote host protective type 2 immunity. We investigate whether adenosine binding to the A

Keywords

Adenosine, Adenosine Triphosphate, Animals, Epithelial Cells, Mice, Mice, Inbred C57BL, Mice, Knockout, Receptor, Adenosine A2B