A Two-Step Transcriptome Analysis of the Human Heart Reveals Broad and Disease-Responsive Expression of Ectopic Olfactory Receptors

Authors

Sadia Ashraf
O Howard Frazier
Sylvia Carranza
David D McPherson
Heinrich Taegtmeyer
Romain Harmancey

Publication Date

9-5-2023

Journal

International Journal of Molecular Sciences

Abstract

G-protein-coupled receptors (GPCRs) are critical regulators of cardiac physiology and a key therapeutic target for the treatment of heart disease. Ectopic olfactory receptors (ORs) are GPCRs expressed in extra-nasal tissues which have recently emerged as new mediators in the metabolic control of cardiac function. The goals of this study were to profile OR gene expression in the human heart, to identify ORs dysregulated by heart failure caused by ischemic cardiomyopathy, and to provide evidence suggestive of a role for those altered ORs in the pathogenesis of heart failure. Left ventricular tissue from heart failure patients (

Keywords

Humans, Receptors, Odorant, Heart, Heart Failure, Heart Diseases, Gene Expression Profiling