Stakeholder Alliances Are Essential To Reduce The Scourge of Plastic Pollution

Authors

Patrick H Kee
Melanie R Moody
Shao-Ling Huang
Hyunggun Kim
Xing Yin
Tao Peng
Susan T Laing
Melvin E Klegerman
Mohammad H Rahbar
Deborah Vela
Curtis Genstler
Kevin J Haworth
Christy K Holland
David D McPherson

Language

English

Publication Date

1-1-2020

Journal

JACC: Basic to Translational Science

DOI

10.1016/j.jacbts.2019.09.005

PMID

32043017

PMCID

PMC7000871

PubMedCentral® Posted Date

November 2019

PubMedCentral® Full Text Version

Post-print

Abstract

Late in-stent restenosis remains a significant problem. Bare-metal stents were implanted into peripheral arteries in miniature swine, followed by direct intra-arterial infusion of nitric oxide-loaded echogenic liposomes (ELIPs) and anti-intercellular adhesion molecule-1 conjugated ELIPs loaded with pioglitazone exposed to an endovascular catheter with an ultrasonic core. Ultrasound-facilitated delivery of ELIP formulations into stented peripheral arteries attenuated neointimal growth. Local atheroma-targeted, ultrasound-triggered delivery of nitric oxide and pioglitazone, an anti-inflammatory peroxisome proliferator-activated receptor-γ agonist, into stented arteries has the potential to stabilize stent-induced neointimal growth and obviate the need for long-term antiplatelet therapy.

Keywords

atherosclerosis, in-stent restenosis, nitric oxide, pioglitazone, ultrasound contrast agent

Published Open-Access

yes

Recommended Citation

Kee, Patrick H; Moody, Melanie R; Huang, Shao-Ling; et al., "Stakeholder Alliances Are Essential To Reduce The Scourge of Plastic Pollution" (2020). Faculty, Staff and Student Publications. 492.
https://digitalcommons.library.tmc.edu/uthmed_docs/492