Exercise-Induced Alterations In Phospholipid Hydrolysis, Airway Surfactant, and Eicosanoids and Their Role In Airway Hyperresponsiveness In Asthma

Authors

Ryan C Murphy
Ying Lai
James D Nolin
Robier A Aguillon Prada
Arindam Chakrabarti
Michael V Novotny
Michael C Seeds
William A Altemeier
Michael H Gelb
Robert Duncan Hite
Teal S Hallstrand

Language

English

Publication Date

5-1-2021

Journal

American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI

10.1152/ajplung.00546.2020

PMID

33533300

PMCID

PMC8174822

PubMedCentral® Posted Date

February 2021

PubMedCentral® Full Text Version

Post-print

Abstract

The mechanisms responsible for driving endogenous airway hyperresponsiveness (AHR) in the form of exercise-induced bronchoconstriction (EIB) are not fully understood. We examined alterations in airway phospholipid hydrolysis, surfactant degradation, and lipid mediator release in relation to AHR severity and changes induced by exercise challenge. Paired induced sputum (

Keywords

Adolescent, Adult, Asthma, Bronchoconstriction, Eicosanoids, Exercise, Female, Group X Phospholipases A2, Humans, Hydrolysis, Male, Osmotic Pressure, Phospholipids, Respiratory Hypersensitivity, Sputum, Surface-Active Agents, Young Adult

Published Open-Access

yes

Recommended Citation

Murphy, Ryan C; Lai, Ying; Nolin, James D; et al., "Exercise-Induced Alterations In Phospholipid Hydrolysis, Airway Surfactant, and Eicosanoids and Their Role In Airway Hyperresponsiveness In Asthma" (2021). Faculty, Staff and Student Publications. 497.
https://digitalcommons.library.tmc.edu/uthmed_docs/497