Exercise-induced alterations in phospholipid hydrolysis, airway surfactant, and eicosanoids and their role in airway hyperresponsiveness in asthma

Authors

Ryan C Murphy
Ying Lai
James D Nolin
Robier A Aguillon Prada
Arindam Chakrabarti
Michael V Novotny
Michael C Seeds
William A Altemeier
Michael H Gelb
Robert Duncan Hite
Teal S Hallstrand

Publication Date

5-1-2021

Journal

American Journal of Physiology-Lung Cellular and Molecular Physiology

Abstract

The mechanisms responsible for driving endogenous airway hyperresponsiveness (AHR) in the form of exercise-induced bronchoconstriction (EIB) are not fully understood. We examined alterations in airway phospholipid hydrolysis, surfactant degradation, and lipid mediator release in relation to AHR severity and changes induced by exercise challenge. Paired induced sputum (

Keywords

Adolescent, Adult, Asthma, Bronchoconstriction, Eicosanoids, Exercise, Female, Group X Phospholipases A2, Humans, Hydrolysis, Male, Osmotic Pressure, Phospholipids, Respiratory Hypersensitivity, Sputum, Surface-Active Agents, Young Adult