UCP3 (Uncoupling Protein 3) Insufficiency Exacerbates Left Ventricular Diastolic Dysfunction During Angiotensin II-Induced Hypertension

Authors

Xu Chen
Sadia Ashraf
Nadia Ashraf
Romain Harmancey

Language

English

Publication Date

9-21-2021

Journal

Journal of the American Heart Association

DOI

10.1161/JAHA.121.022556

PMID

34533037

PMCID

PMC8649532

PubMedCentral® Posted Date

September 2021

PubMedCentral® Full Text Version

Post-print

Abstract

Background Left ventricular diastolic dysfunction, an early stage in the pathogenesis of heart failure with preserved ejection fraction, is exacerbated by joint exposure to hypertension and obesity; however, the molecular mechanisms involved remain uncertain. The mitochondrial UCP3 (uncoupling protein 3) is downregulated in the heart with obesity. Here, we used a rat model of UCP3 haploinsufficiency (ucp3

Keywords

Angiotensin II, Animals, Hypertension, Rats, Uncoupling Protein 3, Ventricular Dysfunction, Left

Published Open-Access

yes

Recommended Citation

Chen, Xu; Ashraf, Sadia; Ashraf, Nadia; et al., "UCP3 (Uncoupling Protein 3) Insufficiency Exacerbates Left Ventricular Diastolic Dysfunction During Angiotensin II-Induced Hypertension" (2021). Faculty, Staff and Student Publications. 523.
https://digitalcommons.library.tmc.edu/uthmed_docs/523