UCP3 (Uncoupling Protein 3) Insufficiency Exacerbates Left Ventricular Diastolic Dysfunction During Angiotensin II-Induced Hypertension

Authors

Xu Chen
Sadia Ashraf
Nadia Ashraf
Romain Harmancey

Publication Date

9-21-2021

Journal

Journal of the American Heart Association

Abstract

Background Left ventricular diastolic dysfunction, an early stage in the pathogenesis of heart failure with preserved ejection fraction, is exacerbated by joint exposure to hypertension and obesity; however, the molecular mechanisms involved remain uncertain. The mitochondrial UCP3 (uncoupling protein 3) is downregulated in the heart with obesity. Here, we used a rat model of UCP3 haploinsufficiency (ucp3

Keywords

Angiotensin II, Animals, Hypertension, Rats, Uncoupling Protein 3, Ventricular Dysfunction, Left

DOI

10.1161/JAHA.121.022556

PMID

34533037

PMCID

PMC8649532

PubMedCentral® Posted Date

September 2021

PubMedCentral® Full Text Version

Post-print

Published Open-Access

yes