Publication Date



Journal of the American Heart Association


Background Left ventricular diastolic dysfunction, an early stage in the pathogenesis of heart failure with preserved ejection fraction, is exacerbated by joint exposure to hypertension and obesity; however, the molecular mechanisms involved remain uncertain. The mitochondrial UCP3 (uncoupling protein 3) is downregulated in the heart with obesity. Here, we used a rat model of UCP3 haploinsufficiency (ucp3


Angiotensin II, Animals, Hypertension, Rats, Uncoupling Protein 3, Ventricular Dysfunction, Left



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