
Faculty, Staff and Student Publications
Publication Date
9-21-2021
Journal
Journal of the American Heart Association
Abstract
Background Left ventricular diastolic dysfunction, an early stage in the pathogenesis of heart failure with preserved ejection fraction, is exacerbated by joint exposure to hypertension and obesity; however, the molecular mechanisms involved remain uncertain. The mitochondrial UCP3 (uncoupling protein 3) is downregulated in the heart with obesity. Here, we used a rat model of UCP3 haploinsufficiency (ucp3
Keywords
Angiotensin II, Animals, Hypertension, Rats, Uncoupling Protein 3, Ventricular Dysfunction, Left
DOI
10.1161/JAHA.121.022556
PMID
34533037
PMCID
PMC8649532
PubMedCentral® Posted Date
September 2021
PubMedCentral® Full Text Version
Post-print
Published Open-Access
yes