Gut Microbiome of Patients With Breast Cancer in Vietnam

Authors

Sang M Nguyen
Huong T T Tran
Jirong Long
Martha J Shrubsole
Hui Cai
Yaohua Yang
Lan M Nguyen
Giang H Nguyen
Chu V Nguyen
To V Ta
Jie Wu
Qiuyin Cai
Wei Zheng
Thuan V Tran
Xiao-Ou Shu

Publication Date

2-1-2024

Journal

JCO Global Oncology

Abstract

PURPOSE: Gut microbiota play an important role in human health, including cancer. Cancer and its treatment, in turn, may alter the gut microbiome. To understand this complex relationship, we profiled the gut microbiome of 356 Vietnamese patients with breast cancer.

MATERIALS AND METHODS: Stool samples were collected before chemotherapy, with 162 pre- and 194 postsurgery. The gut microbiome was measured by shotgun metagenomic sequencing. Associations of gut microbial diversity, taxa abundance, and gut microbiome health index (GMHI) with sociodemographic, clinical factors, and tumor characteristics were evaluated.

RESULTS: Postsurgery samples were associated with significantly lower α- and β-diversities (

CONCLUSION: Our study revealed that diagnosis delay, high fiber intake, and breast cancer surgery, which is always followed by antibiotic prophylaxis in Vietnam, led to a less diverse and unhealthy gut microbiome among patients with breast cancer.

Keywords

Humans, Female, Gastrointestinal Microbiome, Vietnam, Breast Neoplasms, Feces, Metagenome