Multicentric hepatic EBV-associated smooth muscle tumors in an AIDS patient: a case report, investigation of mTOR activation and review of the literature

Authors

Qi Shen
Wei Feng
Michael S Long
Xiuzhen Duan
Siraya Jaijakul
Cesar A Arias
Robert E Brown
Bihong Zhao

Publication Date

4-1-2011

Journal

International Journal of Clinical and Experimental Pathology

Abstract

Epstein-Barr virus (EBV) - associated smooth muscle tumors (EBV-SMT) are a rare, recently recognized distinct group of mesenchymal tumors that develop exclusively in patients with immunosuppression. It is believed that tumorigenesis is, at least in part, through the activation of the Akt/mammalian target of rapamycin (mTOR) signal pathway. We describe the clinicopathologic and immunohistochemical features of a multifocal hepatic EBV-SMT in a 34-year-old acquired immunodeficiency syndrome (AIDS) patient and investigate the activation status of the mTOR signal pathway in this tumor. In addition, we provide a review of the literature on the clinicopathologic findings of hepatic EBV-SMT in adult AIDS patients, and discuss their biologies and possible therapeutic strategies.

Keywords

Epstein-Barr virus, HIV infection, Smooth muscle tumor, acquired immunodeficiency syndrome, adult, liver