Faculty, Staff and Student Publications
Language
English
Publication Date
4-23-2024
Journal
Cell Reports
DOI
10.1016/j.celrep.2024.113993
PMID
38551963
PMCID
PMC11100358
PubMedCentral® Posted Date
May 2024
PubMedCentral® Full Text Version
Author MSS
Abstract
Corticospinal neurons (CSNs) synapse directly on spinal neurons, a diverse assortment of cells with unique structural and functional properties necessary for body movements. CSNs modulating forelimb behavior fractionate into caudal forelimb area (CFA) and rostral forelimb area (RFA) motor cortical populations. Despite their prominence, the full diversity of spinal neurons targeted by CFA and RFA CSNs is uncharted. Here, we use anatomical and RNA sequencing methods to show that CSNs synapse onto a remarkably selective group of spinal cell types, favoring inhibitory populations that regulate motoneuron activity and gate sensory feedback. CFA and RFA CSNs target similar spinal neuron types, with notable exceptions that suggest that these populations differ in how they influence behavior. Finally, axon collaterals of CFA and RFA CSNs target similar brain regions yet receive highly divergent inputs. These results detail the rules of CSN connectivity throughout the brain and spinal cord for two regions critical for forelimb behavior.
Keywords
Animals, Forelimb, Pyramidal Tracts, Spinal Cord, Mice, Motor Cortex, Neurons, Motor Neurons, Female, Male, Axons, Synapses
Published Open-Access
yes
Recommended Citation
Carmona, Lina Marcela; Thomas, Eric D; Smith, Kimberly; et al., "Topographical and Cell Type-Specific Connectivity of Rostral and Caudal Forelimb Corticospinal Neuron Populations" (2024). Faculty, Staff and Student Publications. 777.
https://digitalcommons.library.tmc.edu/uthmed_docs/777