Faculty, Staff and Student Publications
Publication Date
7-13-2023
Journal
Respiratory Research
Abstract
BACKGROUND: Trauma and a subsequent hemorrhagic shock (T/HS) result in insufficient oxygen delivery to tissues and multiple organ failure. Extracellular adenosine, which is a product of the extracellular degradation of adenosine 5' triphosphate (ATP) by the membrane-embedded enzymes CD39 and CD73, is organ protective, as it participates in signaling pathways, which promote cell survival and suppress inflammation through adenosine receptors including the A
METHODS: T/HS shock was induced by blood withdrawal from the femoral artery in wild-type, global knockout (CD39, CD73, A
RESULTS: T/HS upregulated the expression of CD39, CD73, and the A
CONCLUSION: In conclusion, the CD39-CD73-A
Keywords
A2BR, Acute lung injury, Adenosine, CD39, CD73, Trauma hemorrhagic shock