CD73-Generated Extracellular Adenosine Promotes Resolution of Neutrophil-Mediated Tissue Injury and Restrains Metaplasia in Pancreatitis

Authors

Baylee J O'Brien
Erika Y Faraoni
Lincoln N Strickland
Zhibo Ma
Victoria Mota
Samantha Mota
Xuebo Chen
Tingting Mills
Holger K Eltzschig
Kathleen E DelGiorno
Jennifer M Bailey-Lundberg

Publication Date

1-1-2023

Journal

The FASEB Journal

Abstract

Pancreatitis is currently the leading cause of gastrointestinal hospitalizations in the US. This condition occurs in response to abdominal injury, gallstones, chronic alcohol consumption or, less frequently, the cause remains idiopathic. CD73 is a cell surface ecto-5'-nucleotidase that generates extracellular adenosine, which can contribute to resolution of inflammation by binding adenosine receptors on infiltrating immune cells. We hypothesized genetic deletion of CD73 would result in more severe pancreatitis due to decreased generation of extracellular adenosine. CD73 knockout (CD73

Keywords

CD73, acinar-to-ductal metaplasia, inflammation, purinergic signaling