Structural Insights Into Cardiolipin Replacement by Phosphatidylglycerol in a Cardiolipin-lacking Yeast Respiratory Supercomplex

Authors

Corey F Hryc
Venkata K P S Mallampalli
Evgeniy I Bovshik
Stavros Azinas
Guizhen Fan
Irina I Serysheva
Genevieve C Sparagna
Matthew L Baker
Eugenia Mileykovskaya
William Dowhan

Publication Date

5-15-2023

Journal

Nature Communications

Abstract

Cardiolipin is a hallmark phospholipid of mitochondrial membranes. Despite established significance of cardiolipin in supporting respiratory supercomplex organization, a mechanistic understanding of this lipid-protein interaction is still lacking. To address the essential role of cardiolipin in supercomplex organization, we report cryo-EM structures of a wild type supercomplex (IV

Keywords

Saccharomyces cerevisiae, Cardiolipins, Phosphatidylglycerols, Phospholipids, Saccharomyces cerevisiae Proteins