Structural Insights Into Ligand Recognition and Selectivity of Somatostatin Receptors

Authors

Corey F Hryc
Venkata K P S Mallampalli
Evgeniy I Bovshik
Stavros Azinas
Guizhen Fan
Irina I Serysheva
Genevieve C Sparagna
Matthew L Baker
Eugenia Mileykovskaya
William Dowhan

Language

English

Publication Date

5-15-2023

Journal

Nature Communications

DOI

10.1038/s41467-023-38441-5

PMID

37188665

PMCID

PMC10185535

PubMedCentral® Posted Date

May 2023

PubMedCentral® Full Text Version

Post-print

Abstract

Cardiolipin is a hallmark phospholipid of mitochondrial membranes. Despite established significance of cardiolipin in supporting respiratory supercomplex organization, a mechanistic understanding of this lipid-protein interaction is still lacking. To address the essential role of cardiolipin in supercomplex organization, we report cryo-EM structures of a wild type supercomplex (IV

Keywords

Saccharomyces cerevisiae, Cardiolipins, Phosphatidylglycerols, Phospholipids, Saccharomyces cerevisiae Proteins

Published Open-Access

yes

Recommended Citation

Hryc, Corey F; Mallampalli, Venkata K P S; Bovshik, Evgeniy I; et al., "Structural Insights Into Ligand Recognition and Selectivity of Somatostatin Receptors" (2023). Faculty, Staff and Student Publications. 889.
https://digitalcommons.library.tmc.edu/uthmed_docs/889