Activation of Piezo1 Increases The Sensitivity of Breast Cancer To Hyperthermia Therapy

Authors

Shao-Kang Wang
Xiao-Ting Zhang
Xuan-Yao Jiang
Bi-Jiang Geng
Tao-Lin Qing
Lei Li
Yun Chen
Jin-Feng Li
Xiao-Fang Zhang
Shuo-Gui Xu
Jiang-Bo Zhu
Yu-Ping Zhu
Mei-Tang Wang
Ji-Kuai Chen

Language

English

Publication Date

1-1-2024

Journal

Open Medicine

DOI

10.1515/med-2024-0898

PMID

38463518

PMCID

PMC10921451

PubMedCentral® Posted Date

March 2024

PubMedCentral® Full Text Version

Post-print

Abstract

Photothermal therapy (PTT) of nanomaterials is an emerging novel therapeutic strategy for breast cancer. However, there exists an urgent need for appropriate strategies to enhance the antitumor efficacy of PTT and minimize damage to surrounding normal tissues. Piezo1 might be a promising novel photothermal therapeutic target for breast cancer. This study aims to explore the potential role of Piezo1 activation in the hyperthermia therapy of breast cancer cells and investigate the underlying mechanisms. Results showed that the specific agonist of Piezo1 ion channel (Yoda1) aggravated the cell death of breast cancer cells triggered by heat stress

Keywords

photothermal therapy, heat stress, Piezo1, breast cancer

Published Open-Access

yes

Recommended Citation

Wang, Shao-Kang; Zhang, Xiao-Ting; Jiang, Xuan-Yao; et al., "Activation of Piezo1 Increases The Sensitivity of Breast Cancer To Hyperthermia Therapy" (2024). Faculty, Staff and Student Publications. 998.
https://digitalcommons.library.tmc.edu/uthmed_docs/998