Age, Sex, and Apoe Gene-Specific Associations Between Dynapenic Obesity and Dementia in a Large Cohort

Authors

• Zhao Yao
• Jie Wang
• Tianfang Zhang
• Hongjing Ai
• Zeinab Abdelrahman
• Xiaohong Wu
• Daming Wang
• Fenfen Chen
• Ziwei Zhang
• Xiaosheng Wang
• Zuyun Liu
• Zuobing Chen

Language

English

Publication Date

8-1-2024

Journal

The Journal of Nutrition, Health and Aging

DOI

10.1016/j.jnha.2024.100313

PMID

38986174

PMCID

PMC12878627

PubMedCentral® Posted Date

7-9-2024

PubMedCentral® Full Text Version

Post-print

Abstract

Objective: To investigate the associations between dynapenic obesity and the risk of dementia, and the modifying effects of age, sex, and the APOE gene, using a large population-based cohort.

Methods: 279,884 participants aged 55 and above from the UK Biobank were included. The participants were classified into four categories based on body mass index and hand grip strength: healthy, obesity, dynapenia, and dynapenic obesity. The incident dementia was identified based on linked hospital records and death register data. Cox proportional hazards regression models were used to estimate the associations, followed by age-, sex-, and apolipoprotein E (APOE) gene-stratified analyses.

Results: During the median follow-up of 12.4 years, 5,170 (1.8%) participants developed dementia. Compared with the healthy group, participants with dynapenic obesity had 67% higher dementia risk (hazard ratio [HR]: 1.67, 95% confidence interval [CI]: 1.44-1.94). Compared with the healthy group, higher risks of dementia in participants with dynapenic obesity were respectively observed in male (HR: 2.03, 95% CI: 1.65-2.50), younger (< 65 years, HR: 1.97, 95% CI: 1.55-2.50), and non-ε4-carrier (HR: 1.97, 95% CI: 1.60-2.44) (all P for interaction < 0.05). In participants under 65 years and non-ε4-carrier, those with dynapenic obesity had the highest risk of dementia (HR: 2.63, 95% CI: 1.91-3.62), compared with the healthy group (P for second order interaction = 0.026).

Conclusions: Dynapenic obesity is associated with increased risks of dementia, especially in participants under 65 years and non-ε4-carrier, suggesting the importance of managing dynapenic obesity in the prevention of cognition-related disorders.

Keywords

Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Age Factors, Apolipoproteins E, Body Mass Index, Cohort Studies, Dementia, Hand Strength, Obesity, Proportional Hazards Models, Risk Factors, Sex Factors, United Kingdom, Dynapenia, Dynapenic obesity, Dementia, Apolipoprotein E, UK biobank

Published Open-Access

yes

Recommended Citation

Yao, Zhao; Wang, Jie; Zhang, Tianfang; et al., "Age, Sex, and Apoe Gene-Specific Associations Between Dynapenic Obesity and Dementia in a Large Cohort" (2024). Faculty, Staff and Student Publications. 1014.
https://digitalcommons.library.tmc.edu/uthshis_docs/1014