Sox On Tumors, A Comfort Or A Constraint?

Authors

Junqing Jiang
Yufei Wang
Mengyu Sun
Xiangyuan Luo
Zerui Zhang
Yijun Wang
Siwen Li
Dian Hu
Jiaqian Zhang
Zhangfan Wu
Xiaoping Chen
Bixiang Zhang
Xiao Xu
Shuai Wang
Shengjun Xu
Wenjie Huang
Limin Xia

Publication Date

2-9-2024

Journal

Cell Death Discvoery

Abstract

The sex-determining region Y (SRY)-related high-mobility group (HMG) box (SOX) family, composed of 20 transcription factors, is a conserved family with a highly homologous HMG domain. Due to their crucial role in determining cell fate, the dysregulation of SOX family members is closely associated with tumorigenesis, including tumor invasion, metastasis, proliferation, apoptosis, epithelial-mesenchymal transition, stemness and drug resistance. Despite considerable research to investigate the mechanisms and functions of the SOX family, confusion remains regarding aspects such as the role of the SOX family in tumor immune microenvironment (TIME) and contradictory impacts the SOX family exerts on tumors. This review summarizes the physiological function of the SOX family and their multiple roles in tumors, with a focus on the relationship between the SOX family and TIME, aiming to propose their potential role in cancer and promising methods for treatment.

Keywords

Cancer genomics, Cancer immunotherapy

Comments

Associated Data

DOI

10.1038/s41420-024-01834-6

PMID

38331879

PMCID

PMC10853543

PubMedCentral® Posted Date

February 2024

PubMedCentral® Full Text Version

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